Methotrexate and Trimethoprim: High risk — avoid combining interaction. Avoid combining these medicines. Methotrexate and Trimethoprim should be avoided together. Methotrexate toxicity - bone marrow suppression

Drug InteractionHigh Risk — AvoidAI-Verified

Can I take Methotrexate with Trimethoprim?

Methotrexate and Trimethoprim should be avoided together. Methotrexate toxicity - bone marrow suppression

MethotrexateMEDICINE ATrimethoprimMEDICINE B
Avoid combining
Do not combine

Quick verdict

No — avoid combining Methotrexate with Trimethoprim.

Methotrexate and Trimethoprim should be avoided together. Methotrexate toxicity - bone marrow suppression

How They Interact

Methotrexate toxicity - bone marrow suppression

Safety Guidelines

Avoid combination

Why to Avoid

Simple rules that protect you

  • Always tell your doctor/pharmacist about ALL medicines you take — prescriptions, OTC, supplements, and herbal products.
  • Keep a current medicine list with doses and timings — photo on your phone is enough.
  • Read medicine labels for timing (with food / empty stomach) before combining.
  • Do NOT combine Methotrexate with Trimethoprim without explicit doctor approval.
  • Use GoDavaii AI to double-check before adding any new medicine, supplement, or desi ilaaj.

If you've already taken both medicines and feel unwell (unusual bleeding, severe stomach pain, confusion, breathing issues), get medical help now.

Emergency · 112
AI-Verified · Cross-checked against 40,000+ interaction database

Not medical advice

Individual responses vary based on dose, timing, health conditions, and other medicines. Always consult your doctor or pharmacist before combining medicines. For emergencies, call 112.

Frequently Asked Questions

Interaction AI · 22 languages

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Personalized Methotrexate + Trimethoprim interaction review — dose timing, safer alternatives, check against YOUR full medicine list in 22 Indian languages.

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