Can I take Abiraterone with Methotrexate?

CYP3A4 Inducers: Avoid concomitant strong CYP3A4 inducers during abiraterone acetate tablets treatment. If a strong CYP3A4 inducer must be co-administered, increase the abiraterone acetate tablets dosing frequency. (2.5, 7.1) CYP2D6 Substrates: Avoid co-administration of abiraterone acetate tablets with CYP2D6 substrates that have a narrow therapeutic index.

This is general interaction text from the label of a product that contains Abiraterone. It does not mention Methotrexate, so it does not show how Abiraterone and Methotrexate affect each other. The verdict above comes from the GoDavaii interaction dataset. Ask your pharmacist to check both medicines' labels before you combine them.

Questions to ask your pharmacist

• Does Abiraterone change how Methotrexate works, or the other way round?
• Should I take Abiraterone and Methotrexate at different times of day?
• Which side effects should I watch for while taking both?
• Is there a better option if this combination does not suit me?

• Always tell your doctor/pharmacist about ALL medicines you take - prescriptions, OTC, supplements, and herbal products.
• Keep a current medicine list with doses and timings - photo on your phone is enough.
• Read medicine labels for timing (with food / empty stomach) before combining.
• Even 'safe' combinations need monitoring - note any unusual symptoms in the first few days.
• Use GoDavaii AI to double-check before adding any new medicine, supplement, or desi ilaaj.