Immunoglobulin Domains (also known as Domain, Immunoglobulin, Domains, Immunoglobulin): Compact globular protein domains of about 80 to 110 amino acids.They are characterized by two antiparallel beta sheets stabilized by HYDROPHOBIC INTERACTIONS and disulfide bonds between opposing strands. Three major subtypes of Ig d

NIH MeSH · D000070557Phenomena and Processes

Immunoglobulin Domains

Also known asDomain, Immunoglobulin · Domains, Immunoglobulin · Ig Fold · Fold, Ig · Folds, Ig · Ig Folds · Immunoglobulin Domain · Ig Domains · Domain, Ig · Domains, Ig · Ig Domain · Immunoglobulin V-set Domain

Definition

Compact globular protein domains of about 80 to 110 amino acids.They are characterized by two antiparallel beta sheets stabilized by HYDROPHOBIC INTERACTIONS and disulfide bonds between opposing strands. Three major subtypes of Ig domains are recognized: variable (V), intermediate (I), and constant (C1 or C2). Members of the immunoglobulin superfamily include ANTIGEN RECEPTORS; CYTOKINE RECEPTORS; and CELL ADHESION MOLECULES which possess immunoglobulin domains.

MeSH classification

  • G02.111.570.820.709.275.750.250

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Common questions about Immunoglobulin Domains

What does Immunoglobulin Domains mean in medicine?
Compact globular protein domains of about 80 to 110 amino acids.They are characterized by two antiparallel beta sheets stabilized by HYDROPHOBIC INTERACTIONS and disulfide bonds between opposing strands. Three major subtypes of Ig domains are recognized: variable (V), intermediate (I), and constant (C1 or C2). Members of the immunoglobulin superfamily include ANTIGEN RECEPTORS; CYTOKINE RECEPTORS; and CELL ADHESION MOLECULES which possess immunoglobulin domains. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is Immunoglobulin Domains known by any other names?
Yes. Immunoglobulin Domains is also referred to as Domain, Immunoglobulin, Domains, Immunoglobulin, Ig Fold, Fold, Ig in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does Immunoglobulin Domains sit in the medical classification?
Immunoglobulin Domains falls under the broader medical category "Phenomena and Processes" in the MeSH hierarchy (tree numbers: G02.111.570.820.709.275.750.250). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of Immunoglobulin Domains?
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Source: NIH MeSH 2026 (D000070557) — National Library of Medicine, public domain. View official MeSH record ↗