BTB-POZ Domain (also known as BTB POZ Domain, BTB-POZ Domains): A homodimerization protein interaction domain occurring at the N terminus of proteins that contain multiple copies of either CYS2-HIS2 ZINC FINGERS or KELCH REPEATS. It is characterized by a tightly intertwined dimer with an extensive hydrophobic interface

NIH MeSH · D000071757Phenomena and Processes

BTB-POZ Domain

Also known asBTB POZ Domain · BTB-POZ Domains · BTB Domain · BTB Domains · POZ Domain · POZ Domains · BTB (POZ) Domain · Broad-Complex, Tramtrack and Bric a Brac Domain · Broad Complex, Tramtrack and Bric a Brac Domain · POxvirus and Zinc Finger Domain

Definition

A homodimerization protein interaction domain occurring at the N terminus of proteins that contain multiple copies of either CYS2-HIS2 ZINC FINGERS or KELCH REPEATS. It is characterized by a tightly intertwined dimer with an extensive hydrophobic interface. A surface-exposed groove lined with conserved amino acids is formed at the dimer interface, suggesting a peptide-binding site. Many BTB proteins are transcriptional regulators that are thought to regulate CHROMATIN structure.

MeSH classification

  • G02.111.570.820.709.275.750.500.343

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Common questions about BTB-POZ Domain

What does BTB-POZ Domain mean in medicine?
A homodimerization protein interaction domain occurring at the N terminus of proteins that contain multiple copies of either CYS2-HIS2 ZINC FINGERS or KELCH REPEATS. It is characterized by a tightly intertwined dimer with an extensive hydrophobic interface. A surface-exposed groove lined with conserved amino acids is formed at the dimer interface, suggesting a peptide-binding site. Many BTB proteins are transcriptional regulators that are thought to regulate CHROMATIN structure. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is BTB-POZ Domain known by any other names?
Yes. BTB-POZ Domain is also referred to as BTB POZ Domain, BTB-POZ Domains, BTB Domain, BTB Domains in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does BTB-POZ Domain sit in the medical classification?
BTB-POZ Domain falls under the broader medical category "Phenomena and Processes" in the MeSH hierarchy (tree numbers: G02.111.570.820.709.275.750.500.343). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of BTB-POZ Domain?
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Source: NIH MeSH 2026 (D000071757) — National Library of Medicine, public domain. View official MeSH record ↗