C2 Domains (also known as Domain, C2, Domains, C2): Protein modules that function in the targeting of proteins to CELL MEMBRANES. They consist of an eight-stranded anti-parallel beta-sandwich composed of a pair of four-stranded beta-sheets. This structural unit forms a pocket on the membrane-interacting face of the pro

NIH MeSH · D000070538Phenomena and Processes

C2 Domains

Also known asDomain, C2 · Domains, C2 · C2 Domain · C2 Tensin-type Domain · C2 Tensin type Domain · C2 Tensin-type Domains · Domain, C2 Tensin-type · Domains, C2 Tensin-type · Tensin-type Domain, C2 · Tensin-type Domains, C2

Definition

Protein modules that function in the targeting of proteins to CELL MEMBRANES. They consist of an eight-stranded anti-parallel beta-sandwich composed of a pair of four-stranded beta-sheets. This structural unit forms a pocket on the membrane-interacting face of the protein and co-ordinates the binding of 2 to 3 calcium ions; however, not all C2 domains bind calcium. Examples of C2 domain-containing proteins include PROTEIN KINASE C and PTEN PHOSPHOHYDROLASE.

MeSH classification

  • G02.111.570.820.709.275.750.125

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Common questions about C2 Domains

What does C2 Domains mean in medicine?
Protein modules that function in the targeting of proteins to CELL MEMBRANES. They consist of an eight-stranded anti-parallel beta-sandwich composed of a pair of four-stranded beta-sheets. This structural unit forms a pocket on the membrane-interacting face of the protein and co-ordinates the binding of 2 to 3 calcium ions; however, not all C2 domains bind calcium. Examples of C2 domain-containing proteins include PROTEIN KINASE C and PTEN PHOSPHOHYDROLASE. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is C2 Domains known by any other names?
Yes. C2 Domains is also referred to as Domain, C2, Domains, C2, C2 Domain, C2 Tensin-type Domain in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does C2 Domains sit in the medical classification?
C2 Domains falls under the broader medical category "Phenomena and Processes" in the MeSH hierarchy (tree numbers: G02.111.570.820.709.275.750.125). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of C2 Domains?
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Source: NIH MeSH 2026 (D000070538) — National Library of Medicine, public domain. View official MeSH record ↗