C2 Domains
Also known asDomain, C2 · Domains, C2 · C2 Domain · C2 Tensin-type Domain · C2 Tensin type Domain · C2 Tensin-type Domains · Domain, C2 Tensin-type · Domains, C2 Tensin-type · Tensin-type Domain, C2 · Tensin-type Domains, C2
Definition
Protein modules that function in the targeting of proteins to CELL MEMBRANES. They consist of an eight-stranded anti-parallel beta-sandwich composed of a pair of four-stranded beta-sheets. This structural unit forms a pocket on the membrane-interacting face of the protein and co-ordinates the binding of 2 to 3 calcium ions; however, not all C2 domains bind calcium. Examples of C2 domain-containing proteins include PROTEIN KINASE C and PTEN PHOSPHOHYDROLASE.
MeSH classification
- G02.111.570.820.709.275.750.125
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Ankyrin Repeat
Protein motif that contains a 33-amino acid long sequence that often occurs in tandem arrays. This repeating sequence of 33-amino acids was …
B30.2-SPRY Domain
A protein interaction domain that is characterized by a bent beta-sandwich consisting of two antiparallel beta-sheets. It occurs in eukaryot…
BTB-POZ Domain
A homodimerization protein interaction domain occurring at the N terminus of proteins that contain multiple copies of either CYS2-HIS2 ZINC …
Carbohydrate Binding Modules
Contiguous amino acid sequences within a carbohydrate-active enzyme with discrete folds having carbohydrate binding activity. They are class…
Source: NIH MeSH 2026 (D000070538) — National Library of Medicine, public domain. View official MeSH record ↗