Human Challenge Trials: Trials in which participants are intentionally challenged (whether or not they have been vaccinated) with exposure to an infectious disease organism.

NIH MeSH · D000098368Publication Characteristics

Human Challenge Trials

Definition

Trials in which participants are intentionally challenged (whether or not they have been vaccinated) with exposure to an infectious disease organism.

MeSH classification

  • V03.175.250.750

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Common questions about Human Challenge Trials

What does Human Challenge Trials mean in medicine?
Trials in which participants are intentionally challenged (whether or not they have been vaccinated) with exposure to an infectious disease organism. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is Human Challenge Trials known by any other names?
Human Challenge Trials is the canonical name in the MeSH vocabulary. There are no commonly used alternate names for this concept in the official NIH database.
Where does Human Challenge Trials sit in the medical classification?
Human Challenge Trials falls under the broader medical category "Publication Characteristics" in the MeSH hierarchy (tree numbers: V03.175.250.750). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of Human Challenge Trials?
For a plain-language explanation of Human Challenge Trials - including symptoms, treatments and what it means for an Indian patient - ask GoDavaii's Health AI. It works in 22+ Indian languages, is free and needs no signup. Tap "Ask GoDavaii AI about Human Challenge Trials" above.

Source: NIH MeSH 2026 (D000098368) — National Library of Medicine, public domain. View official MeSH record ↗