Human Challenge Trials
Definition
Trials in which participants are intentionally challenged (whether or not they have been vaccinated) with exposure to an infectious disease organism.
MeSH classification
- V03.175.250.750
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Adaptive Clinical Trial
Clinical study in which a prospectively planned opportunity is included to modify trial designs and hypotheses based on analysis of data fro…
Clinical Trial
A work that reports on the results of a clinical study in which participants are assigned to receive one or more interventions so that resea…
Clinical Trial, Phase I
Work that is the report of a pre-planned, usually controlled, clinical study of the safety and efficacy of diagnostic, therapeutic, or proph…
Clinical Trial, Phase II
Work that is a report of a pre-planned, usually controlled, clinical study of the safety and efficacy of diagnostic, therapeutic, or prophyl…
Clinical Trial, Phase III
Work that is a report of a pre-planned, usually controlled, clinical study of the safety and efficacy of diagnostic, therapeutic, or prophyl…
Clinical Trial, Phase IV
Work that is a report of a planned post-marketing study of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques that have …
Controlled Clinical Trial
A work that reports on a clinical trial involving one or more test treatments, at least one control treatment, specified outcome measures fo…
Equivalence Trial
Trial that aims to show a new treatment is no better and no worse than the standard treatment.
Source: NIH MeSH 2026 (D000098368) — National Library of Medicine, public domain. View official MeSH record ↗