Controlled Clinical Trial: A work that reports on a clinical trial involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or proce

NIH MeSH · D018848Publication Characteristics

Controlled Clinical Trial

Definition

A work that reports on a clinical trial involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicine, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trial is characterized as a RANDOMIZED CONTROLLED TRIAL.

MeSH classification

  • V03.175.250.500

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Common questions about Controlled Clinical Trial

What does Controlled Clinical Trial mean in medicine?
A work that reports on a clinical trial involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicine, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trial is characterized as a RANDOMIZED CONTROLLED TRIAL. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is Controlled Clinical Trial known by any other names?
Controlled Clinical Trial is the canonical name in the MeSH vocabulary. There are no commonly used alternate names for this concept in the official NIH database.
Where does Controlled Clinical Trial sit in the medical classification?
Controlled Clinical Trial falls under the broader medical category "Publication Characteristics" in the MeSH hierarchy (tree numbers: V03.175.250.500). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of Controlled Clinical Trial?
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Source: NIH MeSH 2026 (D018848) — National Library of Medicine, public domain. View official MeSH record ↗