AAA Domain (also known as AAA Modules, AAA Module): An approximately 250 amino acid domain common to AAA ATPases and AAA Proteins. It consists of a highly conserved N-terminal P-Loop ATPase subdomain with an alpha-beta-alpha conformation, and a less-conserved C-terminal subdomain with an all alpha conformation. The N-t

NIH MeSH · D000074182Phenomena and Processes

AAA Domain

Also known asAAA Modules · AAA Module · Module, AAA · Modules, AAA · AAA+ Modules · AAA+ Module · Module, AAA+ · Modules, AAA+ · AAA Domains · Domain, AAA · Domains, AAA · AAA+ Domain

Definition

An approximately 250 amino acid domain common to AAA ATPases and AAA Proteins. It consists of a highly conserved N-terminal P-Loop ATPase subdomain with an alpha-beta-alpha conformation, and a less-conserved C-terminal subdomain with an all alpha conformation. The N-terminal subdomain includes Walker A and Walker B motifs which function in ATP binding and hydrolysis.

MeSH classification

  • G02.111.570.820.709.275.500.913

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Related concepts

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Common questions about AAA Domain

What does AAA Domain mean in medicine?
An approximately 250 amino acid domain common to AAA ATPases and AAA Proteins. It consists of a highly conserved N-terminal P-Loop ATPase subdomain with an alpha-beta-alpha conformation, and a less-conserved C-terminal subdomain with an all alpha conformation. The N-terminal subdomain includes Walker A and Walker B motifs which function in ATP binding and hydrolysis. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is AAA Domain known by any other names?
Yes. AAA Domain is also referred to as AAA Modules, AAA Module, Module, AAA, Modules, AAA in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does AAA Domain sit in the medical classification?
AAA Domain falls under the broader medical category "Phenomena and Processes" in the MeSH hierarchy (tree numbers: G02.111.570.820.709.275.500.913). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of AAA Domain?
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Source: NIH MeSH 2026 (D000074182) — National Library of Medicine, public domain. View official MeSH record ↗