AT-Hook Motifs (also known as AT-Hook Motif, AT Hook Motifs): DNA-binding motifs, first described in one of the HMGA PROTEINS: HMG-I(Y) PROTEIN. They consist of positively charged sequences of nine amino acids centered on the invariant tripeptide glycine-arginine-proline. They act to fasten the protein to an AT RICH SE

NIH MeSH · D024761Phenomena and Processes

AT-Hook Motifs

Also known asAT-Hook Motif · AT Hook Motifs · Motif, AT-Hook · Motifs, AT-Hook · AT Hooks · AT Hook · Hook, AT · Hooks, AT · AT Hook Motif · Motif, AT Hook · Motifs, AT Hook

Definition

DNA-binding motifs, first described in one of the HMGA PROTEINS: HMG-I(Y) PROTEIN. They consist of positively charged sequences of nine amino acids centered on the invariant tripeptide glycine-arginine-proline. They act to fasten the protein to an AT RICH SEQUENCE in the DNA.

MeSH classification

  • G02.111.570.820.709.275.500.050

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Related concepts

AAA Domain

An approximately 250 amino acid domain common to AAA ATPases and AAA Proteins. It consists of a highly conserved N-terminal P-Loop ATPase su…

Amino Acid Motifs

Three-dimensional protein structural elements that are composed of a combination of secondary structures. They include HELIX-LOOP-HELIX MOTI…

Ankyrin Repeat

Protein motif that contains a 33-amino acid long sequence that often occurs in tandem arrays. This repeating sequence of 33-amino acids was …

Common questions about AT-Hook Motifs

What does AT-Hook Motifs mean in medicine?
DNA-binding motifs, first described in one of the HMGA PROTEINS: HMG-I(Y) PROTEIN. They consist of positively charged sequences of nine amino acids centered on the invariant tripeptide glycine-arginine-proline. They act to fasten the protein to an AT RICH SEQUENCE in the DNA. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is AT-Hook Motifs known by any other names?
Yes. AT-Hook Motifs is also referred to as AT-Hook Motif, AT Hook Motifs, Motif, AT-Hook, Motifs, AT-Hook in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does AT-Hook Motifs sit in the medical classification?
AT-Hook Motifs falls under the broader medical category "Phenomena and Processes" in the MeSH hierarchy (tree numbers: G02.111.570.820.709.275.500.050). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of AT-Hook Motifs?
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Source: NIH MeSH 2026 (D024761) — National Library of Medicine, public domain. View official MeSH record ↗