Generally SafeFDA B

Is Progesterone Safe During Pregnancy?

Progesterone supplements are safe and often essential to prevent miscarriage in early pregnancy.

Last reviewed: April 2026

Safety Summary

Progesterone supplements are safe and often essential to prevent miscarriage in early pregnancy.

Category B — Likely Safe

Animal studies show no risk, but limited human data available.

Trimester-by-Trimester Guide

1st Trimester (Weeks 1–12)

Often prescribed to prevent miscarriage. Safe and essential if prescribed.

2nd Trimester (Weeks 13–26)

Usually tapered off by week 12-14 unless high-risk.

3rd Trimester (Weeks 27–40)

Rarely needed. Doctor will advise.

Brands Available in India

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Frequently Asked Questions

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Medical Disclaimer: Pregnancy safety information is based on available clinical data and FDA classifications. This page is for educational purposes only and does not substitute professional medical advice. Every pregnancy is different — consult your doctor or gynaecologist before taking any medicine. Drug safety classifications may have been updated; always verify current guidelines.