5-Aminolevulinate Synthetase (also known as 5 Aminolevulinate Synthetase, Synthetase, 5-Aminolevulinate): An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs

NIH MeSH · D000624Chemicals and Drugs

5-Aminolevulinate Synthetase

Also known as5 Aminolevulinate Synthetase · Synthetase, 5-Aminolevulinate · Aminolevulinic Acid Synthetase · Acid Synthetase, Aminolevulinic · Synthetase, Aminolevulinic Acid · delta-Aminolevulinate Synthase · delta Aminolevulinate Synthase · Synthase, delta-Aminolevulinate · delta-Aminolevulinic Acid Synthetase · Acid Synthetase, delta-Aminolevulinic · delta Aminolevulinic Acid Synthetase · Synthetase, delta-Aminolevulinic Acid

Definition

MeSH classification

D08.811.913.050.276

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Common questions about 5-Aminolevulinate Synthetase

What does 5-Aminolevulinate Synthetase mean in medicine?

An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.

Is 5-Aminolevulinate Synthetase known by any other names?

Yes. 5-Aminolevulinate Synthetase is also referred to as 5 Aminolevulinate Synthetase, Synthetase, 5-Aminolevulinate, Aminolevulinic Acid Synthetase, Acid Synthetase, Aminolevulinic in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.

Where does 5-Aminolevulinate Synthetase sit in the medical classification?

5-Aminolevulinate Synthetase falls under the broader medical category "Chemicals and Drugs" in the MeSH hierarchy (tree numbers: D08.811.913.050.276). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.

Where can I get a plain-language explanation of 5-Aminolevulinate Synthetase?

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Source: NIH MeSH 2026 (D000624) — National Library of Medicine, public domain. View official MeSH record ↗