5-Aminolevulinate Synthetase
Also known as5 Aminolevulinate Synthetase · Synthetase, 5-Aminolevulinate · Aminolevulinic Acid Synthetase · Acid Synthetase, Aminolevulinic · Synthetase, Aminolevulinic Acid · delta-Aminolevulinate Synthase · delta Aminolevulinate Synthase · Synthase, delta-Aminolevulinate · delta-Aminolevulinic Acid Synthetase · Acid Synthetase, delta-Aminolevulinic · delta Aminolevulinic Acid Synthetase · Synthetase, delta-Aminolevulinic Acid
Definition
An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.
MeSH classification
- D08.811.913.050.276
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Source: NIH MeSH 2026 (D000624) — National Library of Medicine, public domain. View official MeSH record ↗