2-Isopropylmalate Synthase (also known as 2 Isopropylmalate Synthase, Synthase, 2-Isopropylmalate): An enzyme that catalyzes the first step in the biosynthetic pathway to LEUCINE, forming isopropyl malate from acetyl-CoA and alpha-ketoisovaleric acid. This enzyme was formerly listed as EC 4.1.3.12.

NIH MeSH · D015079Chemicals and Drugs

2-Isopropylmalate Synthase

Also known as2 Isopropylmalate Synthase · Synthase, 2-Isopropylmalate · alpha-Isopropylmalate Synthase · alpha Isopropylmalate Synthase · Synthase, alpha-Isopropylmalate

Definition

An enzyme that catalyzes the first step in the biosynthetic pathway to LEUCINE, forming isopropyl malate from acetyl-CoA and alpha-ketoisovaleric acid. This enzyme was formerly listed as EC 4.1.3.12.

MeSH classification

  • D08.811.913.050.614

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Common questions about 2-Isopropylmalate Synthase

What does 2-Isopropylmalate Synthase mean in medicine?
An enzyme that catalyzes the first step in the biosynthetic pathway to LEUCINE, forming isopropyl malate from acetyl-CoA and alpha-ketoisovaleric acid. This enzyme was formerly listed as EC 4.1.3.12. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is 2-Isopropylmalate Synthase known by any other names?
Yes. 2-Isopropylmalate Synthase is also referred to as 2 Isopropylmalate Synthase, Synthase, 2-Isopropylmalate, alpha-Isopropylmalate Synthase, alpha Isopropylmalate Synthase in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does 2-Isopropylmalate Synthase sit in the medical classification?
2-Isopropylmalate Synthase falls under the broader medical category "Chemicals and Drugs" in the MeSH hierarchy (tree numbers: D08.811.913.050.614). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of 2-Isopropylmalate Synthase?
For a plain-language explanation of 2-Isopropylmalate Synthase - including symptoms, treatments and what it means for an Indian patient - ask GoDavaii's Health AI. It works in 22+ Indian languages, is free and needs no signup. Tap "Ask GoDavaii AI about 2-Isopropylmalate Synthase" above.

Source: NIH MeSH 2026 (D015079) — National Library of Medicine, public domain. View official MeSH record ↗