High Risk Avoid combining

Can I Take Clopidogrel and PPIs (Omeprazole) Together? — Safety Guide

Clopidogrel and PPIs (Omeprazole) should be avoided together. Omeprazole reduces Clopidogrel activation by 40-50%.

Medically Reviewed by GoDavaii Health Team|Updated April 2026

Quick Answer

Clopidogrel and PPIs (Omeprazole) should be avoided together. Omeprazole reduces Clopidogrel activation by 40-50%.

How They Interact

Omeprazole reduces Clopidogrel activation by 40-50%.

Safety Guidelines

Use Pantoprazole instead. Avoid Omeprazole and Esomeprazole.

Important Medical Disclaimer: This drug interaction information is for educational purposes only. Always consult your doctor or pharmacist before combining medicines. Individual responses may vary based on health conditions, dosage, and other factors. GoDavaii's AI assistant can provide additional guidance in 16 Indian languages.

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