Cimetidine and Tramadol Hydrochloride: High risk - avoid combining interaction. Avoid combining these medicines. High risk. Avoid taking Cimetidine with Tramadol Hydrochloride unless your pharmacist or doctor approves.

Drug InteractionHigh Risk - AvoidAI-VerifiedCategory · general

Can I take Cimetidine with Tramadol Hydrochloride?

Cimetidine and Tramadol Hydrochloride should not be combined without explicit medical guidance.

Brand names: Cimetidine - Tagamet (US); Tramadol Hydrochloride - Ultram (US)

CimetidineMEDICINE ATramadol Hydr…MEDICINE B
Avoid combining
Do not combine

Quick verdict

No - avoid combining Cimetidine with Tramadol Hydrochloride.

High Risk - Avoid. Do not combine.

Ask GoDavaii AI about this combination

Is it safe to take Cimetidine with Tramadol Hydrochloride? Explain the interaction, what to watch for, and safer timing.

Interaction text from an FDA label for a product containing Cimetidine (not specific to Tramadol Hydrochloride)

General label text, not a pair-specific study

Drug Interactions Cimetidine tablets, apparently through an effect on certain microsomal enzyme systems, has been reported to reduce the hepatic metabolism of warfarin-type anticoagulants, phenytoin, propranolol, nifedipine, chlordiazepoxide, diazepam, certain tricyclic antidepressants, lidocaine, theophylline, and metronidazole, thereby delaying elimination and increasing blood levels of these dr...

This is general interaction text from the label of a product that contains Cimetidine. It does not mention Tramadol Hydrochloride, so it does not show how Cimetidine and Tramadol Hydrochloride affect each other. The verdict above comes from the GoDavaii interaction dataset. Ask your pharmacist to check both medicines' labels before you combine them.

Questions to ask your pharmacist

  • Does Cimetidine change how Tramadol Hydrochloride works, or the other way round?
  • Should I take Cimetidine and Tramadol Hydrochloride at different times of day?
  • Which side effects should I watch for while taking both?
  • Is there a better option if this combination does not suit me?

Why to Avoid

Simple rules that protect you

  • Always tell your doctor/pharmacist about ALL medicines you take - prescriptions, OTC, supplements, and herbal products.
  • Keep a current medicine list with doses and timings - photo on your phone is enough.
  • Read medicine labels for timing (with food / empty stomach) before combining.
  • Do NOT combine Cimetidine with Tramadol Hydrochloride without explicit doctor approval.
  • Use GoDavaii AI to double-check before adding any new medicine, supplement, or desi ilaaj.

If you've already taken both medicines and feel unwell (unusual bleeding, severe stomach pain, confusion, breathing issues), get medical help now.

Emergency · 112
AI-Verified · Cross-checked against 93,000+ interaction database

Not medical advice

Individual responses vary based on dose, timing, health conditions, and other medicines. Always consult your doctor or pharmacist before combining medicines. For emergencies, call 112.

Source

FDA drug label for Cimetidine (via openFDA). View source ↗

General label text for Cimetidine; not a pair-specific study.

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