Can I take Acalabrutinib with Fluconazole?
Acalabrutinib and Fluconazole should not be combined without explicit medical guidance.
Brand names: Fluconazole - Diflucan (US)
Quick verdict
No - avoid combining Acalabrutinib with Fluconazole.
High Risk - Avoid. Do not combine.
Is it safe to take Acalabrutinib with Fluconazole? Explain the interaction, what to watch for, and safer timing.
Interaction text from an FDA label for a product containing Fluconazole (not specific to Acalabrutinib)
General label text, not a pair-specific study
Drug Interaction Studies (See PRECAUTIONS, Drug Interactions) Oral contraceptives: Oral contraceptives were administered as a single dose both before and after the oral administration of fluconazole 50 mg once daily for 10 days in 10 healthy women. There was no significant difference in ethinyl estradiol or levonorgestrel AUC after the administration of 50 mg of fluconazole.
This is general interaction text from the label of a product that contains Fluconazole. It does not mention Acalabrutinib, so it does not show how Acalabrutinib and Fluconazole affect each other. The verdict above comes from the GoDavaii interaction dataset. Ask your pharmacist to check both medicines' labels before you combine them.
Questions to ask your pharmacist
- Does Acalabrutinib change how Fluconazole works, or the other way round?
- Should I take Acalabrutinib and Fluconazole at different times of day?
- Which side effects should I watch for while taking both?
- Is there a better option if this combination does not suit me?
Why to Avoid
Simple rules that protect you
- Always tell your doctor/pharmacist about ALL medicines you take - prescriptions, OTC, supplements, and herbal products.
- Keep a current medicine list with doses and timings - photo on your phone is enough.
- Read medicine labels for timing (with food / empty stomach) before combining.
- Do NOT combine Acalabrutinib with Fluconazole without explicit doctor approval.
- Use GoDavaii AI to double-check before adding any new medicine, supplement, or desi ilaaj.
If you've already taken both medicines and feel unwell (unusual bleeding, severe stomach pain, confusion, breathing issues), get medical help now.
Emergency · 112Not medical advice
Individual responses vary based on dose, timing, health conditions, and other medicines. Always consult your doctor or pharmacist before combining medicines. For emergencies, call 112.
Source
FDA drug label for Fluconazole (via openFDA). View source ↗
General label text for Fluconazole; not a pair-specific study.
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