D57.4 (Sickle-cell thalassemia) is an umbrella ICD-10-CM medical diagnosis code in the Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism chapter. It identifies cases of sickle-cell thalassemia for clinical documentation, billing and epidemiological tracking.

ICD-10-CM · Category

D57.4 — Sickle-cell thalassemia

Chapter D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

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Sub-codes under D57.4

D57.40Sickle-cell thalassemia without crisis D57.41Sickle-cell thalassemia, unspecified, with crisis D57.42Sickle-cell thalassemia beta zero without crisis D57.43Sickle-cell thalassemia beta zero with crisis D57.44Sickle-cell thalassemia beta plus without crisis D57.45Sickle-cell thalassemia beta plus with crisis

Related diagnoses

D57.0Hb-SS disease with crisis D57.1Sickle-cell disease without crisis D57.2Sickle-cell/Hb-C disease D57.3Sickle-cell trait D57.8Other sickle-cell disorders

Common questions about D57.4 (Sickle-cell thalassemia)

What does ICD-10 code D57.4 mean?

D57.4 is the ICD-10-CM 2025 code for Sickle-cell thalassemia. ICD-10-CM is the medical coding system used by clinicians, hospitals and insurers worldwide to classify diseases and conditions in a standard way.

Is D57.4 a billable diagnosis code?

D57.4 is a category-level (umbrella) code rather than a billable specific code. For billing purposes, clinicians typically use a more specific sub-code under D57.4. Browse the sub-codes listed on this page.

Which ICD-10 chapter does D57.4 belong to?

D57.4 belongs to the chapter "Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism" (codes D50-D89). ICD-10-CM organises codes into 22 chapters by body system or condition type, which helps clinicians navigate related diagnoses.

Where can I get plain-language information about Sickle-cell thalassemia?

For a plain-language explanation of Sickle-cell thalassemia, ask GoDavaii's Health AI - it explains medical conditions in 90+ languages, free, with no signup. Tap "Ask GoDavaii AI about Sickle-cell thalassemia" above to get a personalised answer.

Source: ICD-10-CM 2025 (Centers for Medicare & Medicaid Services, public domain). Codes valid from October 1, 2024. CMS source ↗