Common side effects of Promethazine include Depression (735), Respiratory depression (443), Angioneurotic edema (380). Serious side effects include Hallucination (376) and Hallucinations (376). Promethazine is classified as Medicine. Always consult a doctor if side effects persist.

Side Effects GuideAI-VerifiedMedicine

Promethazine Side Effects

Complete guide to Promethazine side effects — what's common, what's serious, which body systems are affected, and when to see a doctor.

Body impact map

Common
Serious
9+
Common effects
8
Serious effects
4
Body systems

Common Side Effects

Usually mild · often resolve on their own

These side effects may occur in some patients taking Promethazine. Most are mild and improve as your body adjusts. Tell your doctor if any persist or worsen.

Depression (735)
Mental / Nervous
Respiratory depression (443)
Mental / Nervous
Angioneurotic edema (380)
Whole body
Hypotension (46)
Whole body
Urinary tract infection (41)
Kidney
Peripheral edema (39)
Whole body
Bone marrow depression (33)
Mental / Nervous
CNS depression (30)
Mental / Nervous
Gas (506)
Stomach / GI
UTI (468)
Whole body

Serious Side Effects

Rare but urgent · seek immediate medical help

Stop taking Promethazine and seek immediate medical help if any of the following occur. Call 112 for emergencies.

Emergency · 112
Hallucination (376)
Mental / Nervous
Hallucinations (376)
Mental / Nervous
Seizure (166)
Mental / Nervous
Seizures (117)
Mental / Nervous
Anaphylaxis (79)
Whole body
Death (75)
Whole body
Coma (39)
Whole body
Agranulocytosis (1)
Whole body

Not a complete list. Report any unusual symptoms to your doctor immediately.

How to Minimize Side Effects

Simple steps that help

  • Take Promethazine exactly as prescribed by your doctor — never change the dose yourself.
  • Follow dosage timing instructions carefully (with food / empty stomach / at bedtime as directed).
  • Do not stop Promethazine suddenly without consulting your doctor — sudden discontinuation can be risky.
  • Report any new or unusual symptoms to your doctor promptly — early detection prevents complications.
  • Check drug interactions with GoDavaii AI before starting any new medicine, supplement, or even herbal remedy.
  • Avoid alcohol while on Promethazine unless your doctor has confirmed it is safe.
AI-Verified · Cross-checked against 40,000+ interaction database

Not medical advice

Individual responses to Promethazine vary — age, weight, existing conditions, and other medicines all matter. Always consult your doctor for personalized advice. For emergencies, call 112.

Frequently Asked Questions

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