Immunoglobulin Fc Fragments (also known as Fc Fragments, Immunoglobulin, Fc Fragment): Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that ar

NIH MeSH · D007141Chemicals and Drugs

Immunoglobulin Fc Fragments

Also known asFc Fragments, Immunoglobulin · Fc Fragment · Fragment, Fc · Ig Fc Fragments · Fc Fragments, Ig · Fragments, Ig Fc · Fc Fragments · Fc Immunoglobulins · Immunoglobulin Fc Fragment · Fc Fragment, Immunoglobulin · Immunoglobulins, Fc · Fc Immunoglobulin

Definition

Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.

MeSH classification

  • D12.644.541.500.697
  • D12.776.124.486.485.538.500
  • D12.776.124.486.485.680.697
  • D12.776.124.790.651.538.500
  • D12.776.124.790.651.680.660
  • D12.776.377.715.548.538.500
  • D12.776.377.715.548.680.660

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Common questions about Immunoglobulin Fc Fragments

What does Immunoglobulin Fc Fragments mean in medicine?
Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is Immunoglobulin Fc Fragments known by any other names?
Yes. Immunoglobulin Fc Fragments is also referred to as Fc Fragments, Immunoglobulin, Fc Fragment, Fragment, Fc, Ig Fc Fragments in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does Immunoglobulin Fc Fragments sit in the medical classification?
Immunoglobulin Fc Fragments falls under the broader medical category "Chemicals and Drugs" in the MeSH hierarchy (tree numbers: D12.644.541.500.697, D12.776.124.486.485.538.500, D12.776.124.486.485.680.697). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of Immunoglobulin Fc Fragments?
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Source: NIH MeSH 2026 (D007141) — National Library of Medicine, public domain. View official MeSH record ↗