Guanethidine (also known as ((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine, Octadine): An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepine

NIH MeSH · D006145Chemicals and Drugs

Guanethidine

Also known as((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine · Octadine · Oktadin · Isobarin · Guanethidine Sulfate (1:2) · Guanethidine Monosulfate · Monosulfate, Guanethidine · Guanethidine Sulfate (1:1) · Guanethidine Sulfate (2:1), 14C-Labeled · Ismelin · Guanethidine Sulfate · Sulfate, Guanethidine

Definition

An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.

MeSH classification

  • D02.078.370.460

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Related concepts

3-Iodobenzylguanidine

A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used …

Common questions about Guanethidine

What does Guanethidine mean in medicine?
An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is Guanethidine known by any other names?
Yes. Guanethidine is also referred to as ((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine, Octadine, Oktadin, Isobarin in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does Guanethidine sit in the medical classification?
Guanethidine falls under the broader medical category "Chemicals and Drugs" in the MeSH hierarchy (tree numbers: D02.078.370.460). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of Guanethidine?
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Source: NIH MeSH 2026 (D006145) — National Library of Medicine, public domain. View official MeSH record ↗