11-beta-Hydroxysteroid Dehydrogenase Type 2 (also known as 11 beta Hydroxysteroid Dehydrogenase Type 2, 11 beta-HSD2): An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid

NIH MeSH · D043209Chemicals and Drugs

11-beta-Hydroxysteroid Dehydrogenase Type 2

Also known as11 beta Hydroxysteroid Dehydrogenase Type 2 · 11 beta-HSD2 · 11 beta-Hydroxysteroid Dehydrogenase Type 2 · 11beta-HSD2 · 11beta-HSD2 Reductase · 11beta-Hydroxysteroid Dehydrogenase Type 2 · 11beta Hydroxysteroid Dehydrogenase Type 2

Definition

An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.

MeSH classification

  • D08.811.682.047.436.174.600
  • D08.811.682.047.820.100.600

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Related concepts

11-beta-Hydroxysteroid Dehydrogenase Type 1

A low-affinity 11 beta-hydroxysteroid dehydrogenase found in a variety of tissues, most notably in LIVER; LUNG; ADIPOSE TISSUE; vascular tis…

11-beta-Hydroxysteroid Dehydrogenases

Hydroxysteroid dehydrogenases that catalyzes the reversible conversion of CORTISOL to the inactive metabolite CORTISONE. Enzymes in this cla…

Common questions about 11-beta-Hydroxysteroid Dehydrogenase Type 2

What does 11-beta-Hydroxysteroid Dehydrogenase Type 2 mean in medicine?
An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is 11-beta-Hydroxysteroid Dehydrogenase Type 2 known by any other names?
Yes. 11-beta-Hydroxysteroid Dehydrogenase Type 2 is also referred to as 11 beta Hydroxysteroid Dehydrogenase Type 2, 11 beta-HSD2, 11 beta-Hydroxysteroid Dehydrogenase Type 2, 11beta-HSD2 in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does 11-beta-Hydroxysteroid Dehydrogenase Type 2 sit in the medical classification?
11-beta-Hydroxysteroid Dehydrogenase Type 2 falls under the broader medical category "Chemicals and Drugs" in the MeSH hierarchy (tree numbers: D08.811.682.047.436.174.600, D08.811.682.047.820.100.600). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of 11-beta-Hydroxysteroid Dehydrogenase Type 2?
For a plain-language explanation of 11-beta-Hydroxysteroid Dehydrogenase Type 2 - including symptoms, treatments and what it means for an Indian patient - ask GoDavaii's Health AI. It works in 22+ Indian languages, is free and needs no signup. Tap "Ask GoDavaii AI about 11-beta-Hydroxysteroid Dehydrogenase Type 2" above.

Source: NIH MeSH 2026 (D043209) — National Library of Medicine, public domain. View official MeSH record ↗