1-Alkyl-2-acetylglycerophosphocholine Esterase
Also known as1 Alkyl 2 acetylglycerophosphocholine Esterase · Esterase, 1-Alkyl-2-acetylglycerophosphocholine · PAF Acetylhydrolase II · Acetylhydrolase II, PAF · Platelet-Activating Factor Hydrolase · Factor Hydrolase, Platelet-Activating · Hydrolase, Platelet-Activating Factor · Platelet Activating Factor Hydrolase · Lipoprotein-Associated Phospholipase A(2) · Lipoprotein-Associated Phospholipase A2 · Lipoprotein Associated Phospholipase A2 · Phospholipase A2, Lipoprotein-Associated
Definition
A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.
MeSH classification
- D08.811.277.352.100.680.750.937.249
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Ask GoDavaii AI about 1-Alkyl-2-acetylglycerophosphocholine EsteraseSource: NIH MeSH 2026 (D043203) — National Library of Medicine, public domain. View official MeSH record ↗