Can I take Isosorbide Dinitrate with Sildenafil?
Isosorbide Dinitrate and Sildenafil should not be combined without explicit medical guidance.
Brand names: Sildenafil - Viagra (US)
Quick verdict
No - avoid combining Isosorbide Dinitrate with Sildenafil.
What to do: NEVER combine
Is it safe to take Isosorbide Dinitrate with Sildenafil? Explain the interaction, what to watch for, and safer timing.
Interaction text from an FDA label for a product containing Sildenafil (not specific to Isosorbide Dinitrate)
General label text, not a pair-specific study
Sildenafil citrate can potentiate the hypotensive effects of nitrates, alpha blockers, and anti-hypertensives ( 4.1 , 5.5 , 7.1 , 7.2 , 7.3 , 12.2 ) With concomitant use of alpha blockers, initiate sildenafil citrate at 25 mg dose CYP3A4 inhibitors (e.g., ritonavir, ketoconazole, itraconazole, erythromycin): Increase sildenafil citrate exposure ( 2.4 , 7.4 , 12.
This is general interaction text from the label of a product that contains Sildenafil. It does not mention Isosorbide Dinitrate, so it does not show how Isosorbide Dinitrate and Sildenafil affect each other. The verdict above comes from the GoDavaii interaction dataset. Ask your pharmacist to check both medicines' labels before you combine them.
Questions to ask your pharmacist
- Does Isosorbide Dinitrate change how Sildenafil works, or the other way round?
- Should I take Isosorbide Dinitrate and Sildenafil at different times of day?
- Which side effects should I watch for while taking both?
- Is there a better option if this combination does not suit me?
What to do instead
NEVER combine
Why to Avoid
Simple rules that protect you
- NEVER combine
- Always tell your doctor/pharmacist about ALL medicines you take - prescriptions, OTC, supplements, and herbal products.
- Keep a current medicine list with doses and timings - photo on your phone is enough.
- Read medicine labels for timing (with food / empty stomach) before combining.
- Do NOT combine Isosorbide Dinitrate with Sildenafil without explicit doctor approval.
- Use GoDavaii AI to double-check before adding any new medicine, supplement, or desi ilaaj.
If you've already taken both medicines and feel unwell (unusual bleeding, severe stomach pain, confusion, breathing issues), get medical help now.
Emergency · 112Not medical advice
Individual responses vary based on dose, timing, health conditions, and other medicines. Always consult your doctor or pharmacist before combining medicines. For emergencies, call 112.
Source
FDA drug label for Sildenafil (via openFDA). View source ↗
General label text for Sildenafil; not a pair-specific study.
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