Can I take Cimetidine with Letrozole?
Cimetidine and Letrozole should not be combined without explicit medical guidance.
Brand names: Cimetidine - Tagamet (US); Letrozole - Femara (US)
Quick verdict
No - avoid combining Cimetidine with Letrozole.
High Risk - Avoid. Do not combine.
Is it safe to take Cimetidine with Letrozole? Explain the interaction, what to watch for, and safer timing.
Interaction text from an FDA label for a product containing Cimetidine (not specific to Letrozole)
General label text, not a pair-specific study
Drug Interactions Cimetidine tablets, apparently through an effect on certain microsomal enzyme systems, has been reported to reduce the hepatic metabolism of warfarin-type anticoagulants, phenytoin, propranolol, nifedipine, chlordiazepoxide, diazepam, certain tricyclic antidepressants, lidocaine, theophylline, and metronidazole, thereby delaying elimination and increasing blood levels of these dr...
This is general interaction text from the label of a product that contains Cimetidine. It does not mention Letrozole, so it does not show how Cimetidine and Letrozole affect each other. The verdict above comes from the GoDavaii interaction dataset. Ask your pharmacist to check both medicines' labels before you combine them.
Questions to ask your pharmacist
- Does Cimetidine change how Letrozole works, or the other way round?
- Should I take Cimetidine and Letrozole at different times of day?
- Which side effects should I watch for while taking both?
- Is there a better option if this combination does not suit me?
Why to Avoid
Simple rules that protect you
- Always tell your doctor/pharmacist about ALL medicines you take - prescriptions, OTC, supplements, and herbal products.
- Keep a current medicine list with doses and timings - photo on your phone is enough.
- Read medicine labels for timing (with food / empty stomach) before combining.
- Do NOT combine Cimetidine with Letrozole without explicit doctor approval.
- Use GoDavaii AI to double-check before adding any new medicine, supplement, or desi ilaaj.
If you've already taken both medicines and feel unwell (unusual bleeding, severe stomach pain, confusion, breathing issues), get medical help now.
Emergency · 112Not medical advice
Individual responses vary based on dose, timing, health conditions, and other medicines. Always consult your doctor or pharmacist before combining medicines. For emergencies, call 112.
Source
FDA drug label for Cimetidine (via openFDA). View source ↗
General label text for Cimetidine; not a pair-specific study.
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