Amiodarone and Digoxin: High risk — avoid combining interaction. Avoid combining these medicines. FDA label for Amiodarone references interaction with Digoxin. Negative Chronotropes digoxin, beta blockers, verapamil, diltiazem, clonidine, ivabradine Potentiates the electrophysiologic and hemodynamic

Drug InteractionHigh Risk — AvoidAI-VerifiedCategory · general

Can I take Amiodarone with Digoxin?

Amiodarone and Digoxin should not be combined without explicit medical guidance. FDA label for Amiodarone references interaction with Digoxin. Negative Chronotropes digoxin, beta blockers, verapamil, diltiazem, clonidine, ivabradine Potentiates the electrophysiologic and hemodynamic effects of amiodarone, resulting in bradycardia, sinus arrest, and AV block.

AmiodaroneMEDICINE ADigoxinMEDICINE B
Avoid combining
Do not combine

Quick verdict

No — avoid combining Amiodarone with Digoxin.

Amiodarone and Digoxin should not be combined without explicit medical guidance. FDA label for Amiodarone references interaction with Digoxin. Negative Chronotropes digoxin, beta blockers, verapamil, diltiazem, clonidine, ivabradine Potentiates the electrophysiologic and hemodynamic effects of amiodarone, resulting in bradycardia, sinus arrest, and AV block.

How They Interact

The science in one sentence

FDA label for Amiodarone references interaction with Digoxin. Negative Chronotropes digoxin, beta blockers, verapamil, diltiazem, clonidine, ivabradine Potentiates the electrophysiologic and hemodynamic effects of amiodarone, resulting in bradycardia, sinus arrest, and AV block.

Why this matters

FDA label for Amiodarone references interaction with Digoxin. Negative Chronotropes digoxin, beta blockers, verapamil, diltiazem, clonidine, ivabradine Potentiates the electrophysiologic and hemodynamic effects of amiodarone, resulting in bradycardia, sinus arrest, and AV block.

What to do instead

Reduce digoxin dose by 50% when starting amiodarone

Why to Avoid

Simple rules that protect you

  • Reduce digoxin dose by 50% when starting amiodarone
  • Always tell your doctor/pharmacist about ALL medicines you take — prescriptions, OTC, supplements, and herbal products.
  • Keep a current medicine list with doses and timings — photo on your phone is enough.
  • Read medicine labels for timing (with food / empty stomach) before combining.
  • Do NOT combine Amiodarone with Digoxin without explicit doctor approval.
  • Use GoDavaii AI to double-check before adding any new medicine, supplement, or desi ilaaj.

If you've already taken both medicines and feel unwell (unusual bleeding, severe stomach pain, confusion, breathing issues), get medical help now.

Emergency · 112
AI-Verified · Cross-checked against 40,000+ interaction database

Not medical advice

Individual responses vary based on dose, timing, health conditions, and other medicines. Always consult your doctor or pharmacist before combining medicines. For emergencies, call 112.

Frequently Asked Questions

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