Can I take Alpelisib with Sildenafil?

Sildenafil citrate can potentiate the hypotensive effects of nitrates, alpha blockers, and anti-hypertensives ( 4.1 , 5.5 , 7.1 , 7.2 , 7.3 , 12.2 ) With concomitant use of alpha blockers, initiate sildenafil citrate at 25 mg dose CYP3A4 inhibitors (e.g., ritonavir, ketoconazole, itraconazole, erythromycin): Increase sildenafil citrate exposure ( 2.4 , 7.4 , 12.

This is general interaction text from the label of a product that contains Sildenafil. It does not mention Alpelisib, so it does not show how Alpelisib and Sildenafil affect each other. The verdict above comes from the GoDavaii interaction dataset. Ask your pharmacist to check both medicines' labels before you combine them.

Questions to ask your pharmacist

• Does Alpelisib change how Sildenafil works, or the other way round?
• Should I take Alpelisib and Sildenafil at different times of day?
• Which side effects should I watch for while taking both?
• Is there a better option if this combination does not suit me?

• Always tell your doctor/pharmacist about ALL medicines you take - prescriptions, OTC, supplements, and herbal products.
• Keep a current medicine list with doses and timings - photo on your phone is enough.
• Read medicine labels for timing (with food / empty stomach) before combining.
• Even 'safe' combinations need monitoring - note any unusual symptoms in the first few days.
• Use GoDavaii AI to double-check before adding any new medicine, supplement, or desi ilaaj.