Can I take Acalabrutinib with Imatinib?
Acalabrutinib and Imatinib should not be combined without explicit medical guidance.
Brand names: Imatinib - Gleevec (US)
Quick verdict
No - avoid combining Acalabrutinib with Imatinib.
High Risk - Avoid. Do not combine.
Is it safe to take Acalabrutinib with Imatinib? Explain the interaction, what to watch for, and safer timing.
Interaction text from an FDA label for a product containing Imatinib (not specific to Acalabrutinib)
General label text, not a pair-specific study
CYP3A4 inducers may decrease imatinib mesylate C max and area under curve (AUC). ( 2.12 , 7.1 , 12.3 ) CYP3A4 inhibitors may increase imatinib mesylate C max and AUC. ( 7.2 , 12.3 ) Imatinib mesylate is an inhibitor of CYP3A4 and CYP2D6 which may increase the C max and AUC of other drugs. ( 7.3 , 7.4 , 12.
This is general interaction text from the label of a product that contains Imatinib. It does not mention Acalabrutinib, so it does not show how Acalabrutinib and Imatinib affect each other. The verdict above comes from the GoDavaii interaction dataset. Ask your pharmacist to check both medicines' labels before you combine them.
Questions to ask your pharmacist
- Does Acalabrutinib change how Imatinib works, or the other way round?
- Should I take Acalabrutinib and Imatinib at different times of day?
- Which side effects should I watch for while taking both?
- Is there a better option if this combination does not suit me?
Why to Avoid
Simple rules that protect you
- Always tell your doctor/pharmacist about ALL medicines you take - prescriptions, OTC, supplements, and herbal products.
- Keep a current medicine list with doses and timings - photo on your phone is enough.
- Read medicine labels for timing (with food / empty stomach) before combining.
- Do NOT combine Acalabrutinib with Imatinib without explicit doctor approval.
- Use GoDavaii AI to double-check before adding any new medicine, supplement, or desi ilaaj.
If you've already taken both medicines and feel unwell (unusual bleeding, severe stomach pain, confusion, breathing issues), get medical help now.
Emergency · 112Not medical advice
Individual responses vary based on dose, timing, health conditions, and other medicines. Always consult your doctor or pharmacist before combining medicines. For emergencies, call 112.
Source
FDA drug label for Imatinib (via openFDA). View source ↗
General label text for Imatinib; not a pair-specific study.
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