Can I take Abiraterone with Dextromethorphan?
Abiraterone and Dextromethorphan can generally be taken together with standard precautions. FDA label for Abiraterone references interaction with Dextromethorphan. In a CYP2D6 drug-drug interaction trial, the C max and AUC of dextromethorphan (CYP2D6 substrate) were increased 2.8- and 2.9-fold, respectively, when dextromethorphan was given with abiraterone acetate 1,000 mg daily and prednisone 5 mg twice daily.
Brand names: Dextromethorphan - Delsym (US)
Quick verdict
Yes - Abiraterone and Dextromethorphan can usually be combined.
Abiraterone and Dextromethorphan can generally be taken together with standard precautions. FDA label for Abiraterone references interaction with Dextromethorphan. In a CYP2D6 drug-drug interaction trial, the C max and AUC of dextromethorphan (CYP2D6 substrate) were increased 2.8- and 2.9-fold, respectively, when dextromethorphan was given with abiraterone acetate 1,000 mg daily and prednisone 5 mg twice daily.
Is it safe to take Abiraterone with Dextromethorphan? Explain the interaction, what to watch for, and safer timing.
How They Interact
The science in one sentence
FDA label for Abiraterone references interaction with Dextromethorphan. In a CYP2D6 drug-drug interaction trial, the C max and AUC of dextromethorphan (CYP2D6 substrate) were increased 2.8- and 2.9-fold, respectively, when dextromethorphan was given with abiraterone acetate 1,000 mg daily and prednisone 5 mg twice daily.
Why this matters
FDA label for Abiraterone references interaction with Dextromethorphan. In a CYP2D6 drug-drug interaction trial, the C max and AUC of dextromethorphan (CYP2D6 substrate) were increased 2.8- and 2.9-fold, respectively, when dextromethorphan was given with abiraterone acetate 1,000 mg daily and prednisone 5 mg twice daily.
How to Use Smartly
Simple rules that protect you
- Always tell your doctor/pharmacist about ALL medicines you take - prescriptions, OTC, supplements, and herbal products.
- Keep a current medicine list with doses and timings - photo on your phone is enough.
- Read medicine labels for timing (with food / empty stomach) before combining.
- Even 'safe' combinations need monitoring - note any unusual symptoms in the first few days.
- Use GoDavaii AI to double-check before adding any new medicine, supplement, or desi ilaaj.
Not medical advice
Individual responses vary based on dose, timing, health conditions, and other medicines. Always consult your doctor or pharmacist before combining medicines. For emergencies, call 112.
Source
FDA drug label for Abiraterone (via openFDA). View source ↗
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