Can I take Abemaciclib with Leflunomide?

Following oral administration, leflunomide is metabolized to an active metabolite, teriflunomide, which is responsible for essentially all of leflunomide's in vivo activity. Drug interaction studies have been conducted with both leflunomide and with its active metabolite, teriflunomide, where the metabolite was directly administered to the test subjects.

This is general interaction text from the label of a product that contains Leflunomide. It does not mention Abemaciclib, so it does not show how Abemaciclib and Leflunomide affect each other. The verdict above comes from the GoDavaii interaction dataset. Ask your pharmacist to check both medicines' labels before you combine them.

Questions to ask your pharmacist

• Does Abemaciclib change how Leflunomide works, or the other way round?
• Should I take Abemaciclib and Leflunomide at different times of day?
• Which side effects should I watch for while taking both?
• Is there a better option if this combination does not suit me?

• Always tell your doctor/pharmacist about ALL medicines you take - prescriptions, OTC, supplements, and herbal products.
• Keep a current medicine list with doses and timings - photo on your phone is enough.
• Read medicine labels for timing (with food / empty stomach) before combining.
• Do NOT combine Abemaciclib with Leflunomide without explicit doctor approval.
• Use GoDavaii AI to double-check before adding any new medicine, supplement, or desi ilaaj.