Can I take Abemaciclib with Efavirenz?

Consult Full Prescribing Information prior to and during treatment for important potential drug interactions. (4 , 5.4 , 7 ) HIV-1 protease inhibitors: Coadministration of efavirenz, emtricitabine and tenofovir disoproxil fumarate with either lopinavir/ritonavir or darunavir and ritonavir increases tenofovir concentrations. Monitor for evidence of tenofovir toxicity.

This is general interaction text from the label of a product that contains Efavirenz. It does not mention Abemaciclib, so it does not show how Abemaciclib and Efavirenz affect each other. The verdict above comes from the GoDavaii interaction dataset. Ask your pharmacist to check both medicines' labels before you combine them.

Questions to ask your pharmacist

• Does Abemaciclib change how Efavirenz works, or the other way round?
• Should I take Abemaciclib and Efavirenz at different times of day?
• Which side effects should I watch for while taking both?
• Is there a better option if this combination does not suit me?

• Always tell your doctor/pharmacist about ALL medicines you take - prescriptions, OTC, supplements, and herbal products.
• Keep a current medicine list with doses and timings - photo on your phone is enough.
• Read medicine labels for timing (with food / empty stomach) before combining.
• Even 'safe' combinations need monitoring - note any unusual symptoms in the first few days.
• Use GoDavaii AI to double-check before adding any new medicine, supplement, or desi ilaaj.