D89.83 (Cytokine release syndrome) is an umbrella ICD-10-CM medical diagnosis code in the Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism chapter. It identifies cases of cytokine release syndrome for clinical documentation, billing and epidemiological tracking.

ICD-10-CM · Category

D89.83 — Cytokine release syndrome

Chapter D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

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Sub-codes under D89.83

D89.831Cytokine release syndrome, grade 1D89.832Cytokine release syndrome, grade 2D89.833Cytokine release syndrome, grade 3D89.834Cytokine release syndrome, grade 4D89.835Cytokine release syndrome, grade 5D89.839Cytokine release syndrome, grade unspecified

Related diagnoses

D89.81Graft-versus-host diseaseD89.82Autoimmune lymphoproliferative syndrome [ALPS]D89.84IgG4-related diseaseD89.89Oth disrd involving the immune mechanism, NEC

Common questions about D89.83 (Cytokine release syndrome)

What does ICD-10 code D89.83 mean?
D89.83 is the ICD-10-CM 2025 code for Cytokine release syndrome. ICD-10-CM is the medical coding system used by clinicians, hospitals and insurers worldwide to classify diseases and conditions in a standard way.
Is D89.83 a billable diagnosis code?
D89.83 is a category-level (umbrella) code rather than a billable specific code. For billing purposes, clinicians typically use a more specific sub-code under D89.83. Browse the sub-codes listed on this page.
Which ICD-10 chapter does D89.83 belong to?
D89.83 belongs to the chapter "Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism" (codes D50-D89). ICD-10-CM organises codes into 22 chapters by body system or condition type, which helps clinicians navigate related diagnoses.
Where can I get plain-language information about Cytokine release syndrome?
For a plain-language explanation of Cytokine release syndrome, ask GoDavaii's Health AI - it explains medical conditions in 22+ Indian languages, free, with no signup. Tap "Ask GoDavaii AI about Cytokine release syndrome" above to get a personalised answer.

Source: ICD-10-CM 2025 (Centers for Medicare & Medicaid Services, public domain). Codes valid from October 1, 2024. CMS source ↗