D57.21 (Sickle-cell/Hb-C disease with crisis) is an umbrella ICD-10-CM medical diagnosis code in the Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism chapter. It identifies cases of sickle-cell/hb-c disease with crisis for clinical documentation, billing and epidemiolo

ICD-10-CM · Category

D57.21 — Sickle-cell/Hb-C disease with crisis

Chapter D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

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Sub-codes under D57.21

D57.211Sickle-cell/Hb-C disease with acute chest syndromeD57.212Sickle-cell/Hb-C disease with splenic sequestrationD57.213Sickle-cell/Hb-C disease with cerebral vascular involvementD57.214Sickle-cell/Hb-C disease with dactylitisD57.218Sickle-cell/Hb-C disease with crisis with oth complicationD57.219Sickle-cell/Hb-C disease with crisis, unspecified

Related diagnoses

D57.20Sickle-cell/Hb-C disease without crisis

Common questions about D57.21 (Sickle-cell/Hb-C disease with crisis)

What does ICD-10 code D57.21 mean?
D57.21 is the ICD-10-CM 2025 code for Sickle-cell/Hb-C disease with crisis. ICD-10-CM is the medical coding system used by clinicians, hospitals and insurers worldwide to classify diseases and conditions in a standard way.
Is D57.21 a billable diagnosis code?
D57.21 is a category-level (umbrella) code rather than a billable specific code. For billing purposes, clinicians typically use a more specific sub-code under D57.21. Browse the sub-codes listed on this page.
Which ICD-10 chapter does D57.21 belong to?
D57.21 belongs to the chapter "Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism" (codes D50-D89). ICD-10-CM organises codes into 22 chapters by body system or condition type, which helps clinicians navigate related diagnoses.
Where can I get plain-language information about Sickle-cell/Hb-C disease with crisis?
For a plain-language explanation of Sickle-cell/Hb-C disease with crisis, ask GoDavaii's Health AI - it explains medical conditions in 90+ languages, free, with no signup. Tap "Ask GoDavaii AI about Sickle-cell/Hb-C disease with crisis" above to get a personalised answer.

Source: ICD-10-CM 2025 (Centers for Medicare & Medicaid Services, public domain). Codes valid from October 1, 2024. CMS source ↗