Transducin (also known as G-Protein, Inhibitory Gt, G Protein, Inhibitory Gt): A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod an
NIH MeSH · D015293Chemicals and Drugs
Transducin
Also known asG-Protein, Inhibitory Gt · G Protein, Inhibitory Gt · Gt G-Protein, Inhibitory · Inhibitory Gt G-Protein · Transducin G-Protein (Gt) · Gt, Transducin G-Protein · G-Protein Gt, Transducin · Gt, Transducin G Protein · Transducin G-Protein Gt · alpha-Transducin · alpha Transducin · Transducin, alpha Subunit
Definition
A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod and cone cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore hyperpolarization of the rod cells.
MeSH classification
D08.811.277.040.330.300.200.800
D12.776.157.325.332.940
D12.776.476.338.200.800
D12.776.543.325.800
Need clinical context, treatments, or patient-language explanation?
A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod and cone cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore hyperpolarization of the rod cells. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is Transducin known by any other names?
Yes. Transducin is also referred to as G-Protein, Inhibitory Gt, G Protein, Inhibitory Gt, Gt G-Protein, Inhibitory, Inhibitory Gt G-Protein in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does Transducin sit in the medical classification?
Transducin falls under the broader medical category "Chemicals and Drugs" in the MeSH hierarchy (tree numbers: D08.811.277.040.330.300.200.800, D12.776.157.325.332.940, D12.776.476.338.200.800). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of Transducin?
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