Shwartzman Phenomenon (also known as Phenomenon, Shwartzman, Schwartzman Reaction): Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (ENDOTOXINS) followed by a second intravenous endotoxin injec
NIH MeSH · D012790Diseases
Shwartzman Phenomenon
Also known asPhenomenon, Shwartzman · Schwartzman Reaction · Schwartzman Reactions · Shwartzman Reaction · Schwartzman Phenomenon · Phenomenon, Schwartzman
Definition
Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (ENDOTOXINS) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous THROMBOSIS and NECROSIS. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of IMMUNE SYSTEM, coagulation, FIBRINOLYSIS, and blood flow.
MeSH classification
C14.907.454.810
C14.907.940.890
C15.378.463.515.810
Need clinical context, treatments, or patient-language explanation?
Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (ENDOTOXINS) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous THROMBOSIS and NECROSIS. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of IMMUNE SYSTEM, coagulation, FIBRINOLYSIS, and blood flow. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is Shwartzman Phenomenon known by any other names?
Yes. Shwartzman Phenomenon is also referred to as Phenomenon, Shwartzman, Schwartzman Reaction, Schwartzman Reactions, Shwartzman Reaction in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does Shwartzman Phenomenon sit in the medical classification?
Shwartzman Phenomenon falls under the broader medical category "Diseases" in the MeSH hierarchy (tree numbers: C14.907.454.810, C14.907.940.890, C15.378.463.515.810). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of Shwartzman Phenomenon?
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