RNA-Induced Silencing Complex (also known as Complex, RNA-Induced Silencing, RNA Induced Silencing Complex): A multicomponent, ribonucleoprotein complex comprised of one of the family of ARGONAUTE PROTEINS and the guide strand of the one of the 20- to 30-nucleotide small RNAs. RISC cleaves specific RNAs, which are targ
A multicomponent, ribonucleoprotein complex comprised of one of the family of ARGONAUTE PROTEINS and the guide strand of the one of the 20- to 30-nucleotide small RNAs. RISC cleaves specific RNAs, which are targeted for degradation by homology to these small RNAs. Functions in regulating gene expression are determined by the specific argonaute protein and small RNA including siRNA (RNA, SMALL INTERFERING), miRNA (MICRORNA), or piRNA (PIWI-INTERACTING RNA).
MeSH classification
D08.811.277.352.355.350.810
D08.811.277.352.700.350.810
D12.776.157.725.500.906
D12.776.664.962.500.906
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Common questions about RNA-Induced Silencing Complex
What does RNA-Induced Silencing Complex mean in medicine?
A multicomponent, ribonucleoprotein complex comprised of one of the family of ARGONAUTE PROTEINS and the guide strand of the one of the 20- to 30-nucleotide small RNAs. RISC cleaves specific RNAs, which are targeted for degradation by homology to these small RNAs. Functions in regulating gene expression are determined by the specific argonaute protein and small RNA including siRNA (RNA, SMALL INTERFERING), miRNA (MICRORNA), or piRNA (PIWI-INTERACTING RNA). This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is RNA-Induced Silencing Complex known by any other names?
Yes. RNA-Induced Silencing Complex is also referred to as Complex, RNA-Induced Silencing, RNA Induced Silencing Complex, Silencing Complex, RNA-Induced, RISC Multicomponent Nuclease in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does RNA-Induced Silencing Complex sit in the medical classification?
RNA-Induced Silencing Complex falls under the broader medical category "Chemicals and Drugs" in the MeSH hierarchy (tree numbers: D08.811.277.352.355.350.810, D08.811.277.352.700.350.810, D12.776.157.725.500.906). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of RNA-Induced Silencing Complex?
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