Neutralization Tests (also known as Neutralization Test, Test, Neutralization): The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures de

NIH MeSH · D009500Analytical, Diagnostic and Therapeutic Techniques and Equipment

Neutralization Tests

Also known asNeutralization Test · Test, Neutralization · Tests, Neutralization

Definition

The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).

MeSH classification

  • E01.370.225.812.735.550
  • E05.200.812.735.550
  • E05.478.594.760.550

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Related concepts

Agglutination Tests

Tests that are dependent on the clumping of cells, microorganisms, or particles when mixed with specific antiserum. (From Stedman, 26th ed)

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Common questions about Neutralization Tests

What does Neutralization Tests mean in medicine?
The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50). This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is Neutralization Tests known by any other names?
Yes. Neutralization Tests is also referred to as Neutralization Test, Test, Neutralization, Tests, Neutralization in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does Neutralization Tests sit in the medical classification?
Neutralization Tests falls under the broader medical category "Analytical, Diagnostic and Therapeutic Techniques and Equipment" in the MeSH hierarchy (tree numbers: E01.370.225.812.735.550, E05.200.812.735.550, E05.478.594.760.550). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of Neutralization Tests?
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Source: NIH MeSH 2026 (D009500) — National Library of Medicine, public domain. View official MeSH record ↗