Kallmann Syndrome (also known as Syndrome, Kallmann, Anosmic Hypogonadism): A genetically heterogeneous disorder caused by hypothalamic GNRH deficiency and OLFACTORY NERVE defects. It is characterized by congenital HYPOGONADOTROPIC HYPOGONADISM and ANOSMIA, possibly with additional midline defects. It can be transmitte
NIH MeSH · D017436Diseases
Kallmann Syndrome
Also known asSyndrome, Kallmann · Anosmic Hypogonadism · Anosmic Hypogonadisms · Hypogonadism, Anosmic · Hypogonadisms, Anosmic · Anosmic Idiopathic Hypogonadotropic Hypogonadism · Dysplasia Olfactogenitalis of De Morsier · Hypogonadotropic Hypogonadism and Anosmia · Hypogonadotropic Hypogonadism-Anosmia Syndrome · Kallmann's Syndrome · Kallmanns Syndrome · Syndrome, Kallmann's
Definition
A genetically heterogeneous disorder caused by hypothalamic GNRH deficiency and OLFACTORY NERVE defects. It is characterized by congenital HYPOGONADOTROPIC HYPOGONADISM and ANOSMIA, possibly with additional midline defects. It can be transmitted as an X-linked (GENETIC DISEASES, X-LINKED), an autosomal dominant, or an autosomal recessive trait.
MeSH classification
C12.050.351.875.253.096.750
C12.200.706.316.096.750
C12.800.316.096.750
C16.131.939.316.096.750
C16.320.467
C19.391.119.096.750
C19.391.482.600
Need clinical context, treatments, or patient-language explanation?
A genetically heterogeneous disorder caused by hypothalamic GNRH deficiency and OLFACTORY NERVE defects. It is characterized by congenital HYPOGONADOTROPIC HYPOGONADISM and ANOSMIA, possibly with additional midline defects. It can be transmitted as an X-linked (GENETIC DISEASES, X-LINKED), an autosomal dominant, or an autosomal recessive trait. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is Kallmann Syndrome known by any other names?
Yes. Kallmann Syndrome is also referred to as Syndrome, Kallmann, Anosmic Hypogonadism, Anosmic Hypogonadisms, Hypogonadism, Anosmic in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does Kallmann Syndrome sit in the medical classification?
Kallmann Syndrome falls under the broader medical category "Diseases" in the MeSH hierarchy (tree numbers: C12.050.351.875.253.096.750, C12.200.706.316.096.750, C12.800.316.096.750). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of Kallmann Syndrome?
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