Job Syndrome (also known as Job Syndromes, Syndrome, Job): Primary immunodeficiency syndrome characterized by recurrent infections and hyperimmunoglobulinemia E. Most cases are sporadic. Of the rare familial forms, the dominantly inherited subtype has additional connective tissue, dental and skeletal involvement that t
NIH MeSH · D007589Diseases
Job Syndrome
Also known asJob Syndromes · Syndrome, Job · Syndromes, Job · Buckley Syndrome · Buckley Syndromes · HIE Syndrome · HIE Syndromes · Hyper-Ige Recurrent Infection Syndrome, Autosomal Dominant · Hyper-IgE Syndrome · Hyper IgE Syndrome · Hyper-IgE Syndromes · Hyperimmunoglobulin E, Recurrent Infection Syndrome
Definition
Primary immunodeficiency syndrome characterized by recurrent infections and hyperimmunoglobulinemia E. Most cases are sporadic. Of the rare familial forms, the dominantly inherited subtype has additional connective tissue, dental and skeletal involvement that the recessive type does not share.
MeSH classification
C15.378.553.774.600
C16.320.798.688
C20.673.774.600
C20.673.795.688
Need clinical context, treatments, or patient-language explanation?
Primary immunodeficiency syndrome characterized by recurrent infections and hyperimmunoglobulinemia E. Most cases are sporadic. Of the rare familial forms, the dominantly inherited subtype has additional connective tissue, dental and skeletal involvement that the recessive type does not share. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is Job Syndrome known by any other names?
Yes. Job Syndrome is also referred to as Job Syndromes, Syndrome, Job, Syndromes, Job, Buckley Syndrome in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does Job Syndrome sit in the medical classification?
Job Syndrome falls under the broader medical category "Diseases" in the MeSH hierarchy (tree numbers: C15.378.553.774.600, C16.320.798.688, C20.673.774.600). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of Job Syndrome?
For a plain-language explanation of Job Syndrome - including symptoms, treatments and what it means for an Indian patient - ask GoDavaii's Health AI. It works in 22+ Indian languages, is free and needs no signup. Tap "Ask GoDavaii AI about Job Syndrome" above.