Extracellular Space (also known as Extracellular Spaces, Space, Extracellular): Interstitial space between cells, occupied by INTERSTITIAL FLUID as well as amorphous and fibrous substances. For organisms with a CELL WALL, the extracellular space includes everything outside of the CELL MEMBRANE including the PERIPLASM a

NIH MeSH · D005110Anatomy

Extracellular Space

Also known asExtracellular Spaces · Space, Extracellular · Spaces, Extracellular · Intercellular Space · Intercellular Spaces · Space, Intercellular · Spaces, Intercellular

Definition

Interstitial space between cells, occupied by INTERSTITIAL FLUID as well as amorphous and fibrous substances. For organisms with a CELL WALL, the extracellular space includes everything outside of the CELL MEMBRANE including the PERIPLASM and the cell wall.

MeSH classification

  • A10.082.500
  • A11.284.295

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Related concepts

Body Fluid Compartments

The two types of spaces between which water and other body fluids are distributed: extracellular and intracellular.

Common questions about Extracellular Space

What does Extracellular Space mean in medicine?
Interstitial space between cells, occupied by INTERSTITIAL FLUID as well as amorphous and fibrous substances. For organisms with a CELL WALL, the extracellular space includes everything outside of the CELL MEMBRANE including the PERIPLASM and the cell wall. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is Extracellular Space known by any other names?
Yes. Extracellular Space is also referred to as Extracellular Spaces, Space, Extracellular, Spaces, Extracellular, Intercellular Space in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does Extracellular Space sit in the medical classification?
Extracellular Space falls under the broader medical category "Anatomy" in the MeSH hierarchy (tree numbers: A10.082.500, A11.284.295). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of Extracellular Space?
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Source: NIH MeSH 2026 (D005110) — National Library of Medicine, public domain. View official MeSH record ↗