Deoxyribonuclease I (also known as DNase I, Pancreatic DNase): An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enz

NIH MeSH · D003850Chemicals and Drugs

Deoxyribonuclease I

Also known asDNase I · Pancreatic DNase · DNase, Pancreatic · Thymonuclease · DNAase I · DNA Endonuclease · Endonuclease, DNA · Streptodornase · T4-Endonuclease II · T4 Endonuclease II · Nickase · DNA Nicking Enzyme

Definition

An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.

MeSH classification

  • D08.811.277.352.335.350.250

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Common questions about Deoxyribonuclease I

What does Deoxyribonuclease I mean in medicine?
An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is Deoxyribonuclease I known by any other names?
Yes. Deoxyribonuclease I is also referred to as DNase I, Pancreatic DNase, DNase, Pancreatic, Thymonuclease in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does Deoxyribonuclease I sit in the medical classification?
Deoxyribonuclease I falls under the broader medical category "Chemicals and Drugs" in the MeSH hierarchy (tree numbers: D08.811.277.352.335.350.250). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of Deoxyribonuclease I?
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Source: NIH MeSH 2026 (D003850) — National Library of Medicine, public domain. View official MeSH record ↗