Cholera Toxin (also known as Toxin, Cholera, Cholera Enterotoxin CT): An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fr
NIH MeSH · D002772Chemicals and Drugs
Cholera Toxin
Also known asToxin, Cholera · Cholera Enterotoxin CT · Enterotoxin CT, Cholera · Cholera Exotoxin · Exotoxin, Cholera · Choleragen · Choleragenoid · Cholera Toxin Subunit B · Cholera Toxin B · Toxin B, Cholera · Cholera Toxin B Subunit · Cholera Toxin Protomer B
Definition
An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
MeSH classification
D08.811.913.400.725.115.180
D23.946.123.194
D23.946.330.150
Need clinical context, treatments, or patient-language explanation?
An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is Cholera Toxin known by any other names?
Yes. Cholera Toxin is also referred to as Toxin, Cholera, Cholera Enterotoxin CT, Enterotoxin CT, Cholera, Cholera Exotoxin in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does Cholera Toxin sit in the medical classification?
Cholera Toxin falls under the broader medical category "Chemicals and Drugs" in the MeSH hierarchy (tree numbers: D08.811.913.400.725.115.180, D23.946.123.194, D23.946.330.150). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of Cholera Toxin?
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