Centrifugation, Isopycnic (also known as Isopycnic Centrifugation): A technique used to separate particles according to their densities in a continuous density gradient. The sample is usually mixed with a solution of known gradient materials and subjected to centrifugation. Each particle sediments to the position at wh

NIH MeSH · D002500Analytical, Diagnostic and Therapeutic Techniques and Equipment

Centrifugation, Isopycnic

Also known asIsopycnic Centrifugation

Definition

A technique used to separate particles according to their densities in a continuous density gradient. The sample is usually mixed with a solution of known gradient materials and subjected to centrifugation. Each particle sediments to the position at which the gradient density is equal to its own. The range of the density gradient is usually greater than that of the sample particles. It is used in purifying biological materials such as proteins, nucleic acids, organelles, and cell types.

MeSH classification

  • E05.181.724.336.253
  • E05.196.941.336.253

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Common questions about Centrifugation, Isopycnic

What does Centrifugation, Isopycnic mean in medicine?
A technique used to separate particles according to their densities in a continuous density gradient. The sample is usually mixed with a solution of known gradient materials and subjected to centrifugation. Each particle sediments to the position at which the gradient density is equal to its own. The range of the density gradient is usually greater than that of the sample particles. It is used in purifying biological materials such as proteins, nucleic acids, organelles, and cell types. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is Centrifugation, Isopycnic known by any other names?
Yes. Centrifugation, Isopycnic is also referred to as Isopycnic Centrifugation in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does Centrifugation, Isopycnic sit in the medical classification?
Centrifugation, Isopycnic falls under the broader medical category "Analytical, Diagnostic and Therapeutic Techniques and Equipment" in the MeSH hierarchy (tree numbers: E05.181.724.336.253, E05.196.941.336.253). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of Centrifugation, Isopycnic?
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Source: NIH MeSH 2026 (D002500) — National Library of Medicine, public domain. View official MeSH record ↗