Amino Acid Substitution (also known as Amino Acid Substitutions, Substitution, Amino Acid): The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution

NIH MeSH · D019943Analytical, Diagnostic and Therapeutic Techniques and Equipment

Amino Acid Substitution

Also known asAmino Acid Substitutions · Substitution, Amino Acid · Substitutions, Amino Acid

Definition

The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.

MeSH classification

  • E05.393.420.601.035
  • G05.558.109

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Common questions about Amino Acid Substitution

What does Amino Acid Substitution mean in medicine?
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is Amino Acid Substitution known by any other names?
Yes. Amino Acid Substitution is also referred to as Amino Acid Substitutions, Substitution, Amino Acid, Substitutions, Amino Acid in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does Amino Acid Substitution sit in the medical classification?
Amino Acid Substitution falls under the broader medical category "Analytical, Diagnostic and Therapeutic Techniques and Equipment" in the MeSH hierarchy (tree numbers: E05.393.420.601.035, G05.558.109). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of Amino Acid Substitution?
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Source: NIH MeSH 2026 (D019943) — National Library of Medicine, public domain. View official MeSH record ↗