Activated Protein C Resistance (also known as APC Resistance, Resistance, APC): A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most commo

NIH MeSH · D020016Diseases

Activated Protein C Resistance

Also known asAPC Resistance · Resistance, APC

Definition

A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance.

MeSH classification

  • C15.378.100.100.037
  • C15.378.100.141.036
  • C15.378.925.050
  • C16.320.099.037

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Related concepts

Afibrinogenemia

A deficiency or absence of FIBRINOGEN in the blood.

Common questions about Activated Protein C Resistance

What does Activated Protein C Resistance mean in medicine?
A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is Activated Protein C Resistance known by any other names?
Yes. Activated Protein C Resistance is also referred to as APC Resistance, Resistance, APC in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does Activated Protein C Resistance sit in the medical classification?
Activated Protein C Resistance falls under the broader medical category "Diseases" in the MeSH hierarchy (tree numbers: C15.378.100.100.037, C15.378.100.141.036, C15.378.925.050). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of Activated Protein C Resistance?
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Source: NIH MeSH 2026 (D020016) — National Library of Medicine, public domain. View official MeSH record ↗