Acantholysis (also known as Acantholyses): Separation of the prickle cells of the stratum spinosum of the epidermis, resulting in atrophy of the prickle cell layer. It is seen in diseases such as pemphigus vulgaris (see PEMPHIGUS) and DARIER DISEASE.

NIH MeSH · D000051Diseases

Acantholysis

Also known asAcantholyses

Definition

Separation of the prickle cells of the stratum spinosum of the epidermis, resulting in atrophy of the prickle cell layer. It is seen in diseases such as pemphigus vulgaris (see PEMPHIGUS) and DARIER DISEASE.

MeSH classification

  • C17.800.865.070
  • C23.550.035

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Common questions about Acantholysis

What does Acantholysis mean in medicine?
Separation of the prickle cells of the stratum spinosum of the epidermis, resulting in atrophy of the prickle cell layer. It is seen in diseases such as pemphigus vulgaris (see PEMPHIGUS) and DARIER DISEASE. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is Acantholysis known by any other names?
Yes. Acantholysis is also referred to as Acantholyses in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does Acantholysis sit in the medical classification?
Acantholysis falls under the broader medical category "Diseases" in the MeSH hierarchy (tree numbers: C17.800.865.070, C23.550.035). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of Acantholysis?
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Source: NIH MeSH 2026 (D000051) — National Library of Medicine, public domain. View official MeSH record ↗