Abuse-Deterrent Formulations

Drug formulations or delivery systems intended to discourage the abuse of CONTROLLED SUBSTANCES. These may include physical barriers to prevent chewing or crushing the drug; chemical barriers that prevent extraction of psychoactive ingredients; agonist-antagonist combinations to reduce euphoria associated with abuse; aversion, where controlled substances are combined with others that will produce an unpleasant effect if the patient manipulates the dosage form or exceeds the recommended dose; delivery systems that are resistant to abuse such as implants; or combinations of these methods. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.

Yes. Abuse-Deterrent Formulations is also referred to as Abuse Deterrent Formulations, Abuse-Deterrent Formulation, Abuse Deterrent Formulation, Formulation, Abuse-Deterrent in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.

Abuse-Deterrent Formulations falls under the broader medical category "Chemicals and Drugs" in the MeSH hierarchy (tree numbers: D26.255.075, D27.505.696.034, D27.505.696.663.850.007). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.

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