2-Amino-5-phosphonovalerate (also known as 2 Amino 5 phosphonovalerate, 2-APV): The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid rec

NIH MeSH · D015763Chemicals and Drugs

2-Amino-5-phosphonovalerate

Also known as2 Amino 5 phosphonovalerate · 2-APV · 5-Phosphononorvaline · 5 Phosphononorvaline · 2-Amino-5-phosphonopentanoate · 2 Amino 5 phosphonopentanoate · 2-Amino-5-phosphonopentanoic Acid · 2 Amino 5 phosphonopentanoic Acid · 2-Amino-5-phosphonovaleric Acid · 2 Amino 5 phosphonovaleric Acid · d-APV · dl-APV

Definition

The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.

MeSH classification

  • D12.125.070.950.100
  • D12.125.740.025

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Common questions about 2-Amino-5-phosphonovalerate

What does 2-Amino-5-phosphonovalerate mean in medicine?
The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is 2-Amino-5-phosphonovalerate known by any other names?
Yes. 2-Amino-5-phosphonovalerate is also referred to as 2 Amino 5 phosphonovalerate, 2-APV, 5-Phosphononorvaline, 5 Phosphononorvaline in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does 2-Amino-5-phosphonovalerate sit in the medical classification?
2-Amino-5-phosphonovalerate falls under the broader medical category "Chemicals and Drugs" in the MeSH hierarchy (tree numbers: D12.125.070.950.100, D12.125.740.025). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of 2-Amino-5-phosphonovalerate?
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Source: NIH MeSH 2026 (D015763) — National Library of Medicine, public domain. View official MeSH record ↗