1-Pyrroline-5-Carboxylate Dehydrogenase (also known as 1 Pyrroline 5 Carboxylate Dehydrogenase, Dehydrogenase, 1-Pyrroline-5-Carboxylate): An enzyme that catalyzes the oxidation of 1-pyrroline-5-carboxylate to L-GLUTAMATE in the presence of NAD. Defects in the enzyme are the cause of hyperprolinemia II.

NIH MeSH · D050842Chemicals and Drugs

1-Pyrroline-5-Carboxylate Dehydrogenase

Also known as1 Pyrroline 5 Carboxylate Dehydrogenase · Dehydrogenase, 1-Pyrroline-5-Carboxylate · GGS Dehydrogenase · Dehydrogenase, GGS · NADP+ Specific 8-Glutamate Semialdehyde Dehydrogenase · NADP+ Specific 8 Glutamate Semialdehyde Dehydrogenase · Delta(1)-Pyrroline-5-Carboxylate Dehydrogenase · Glutamic-Gamma-Semialdehyde Dehydrogenase · Dehydrogenase, Glutamic-Gamma-Semialdehyde · Glutamic Gamma Semialdehyde Dehydrogenase · Glutamyl-Gamma-Semialdehyde Dehydrogenase · Dehydrogenase, Glutamyl-Gamma-Semialdehyde

Definition

An enzyme that catalyzes the oxidation of 1-pyrroline-5-carboxylate to L-GLUTAMATE in the presence of NAD. Defects in the enzyme are the cause of hyperprolinemia II.

MeSH classification

  • D08.811.682.662.693

Need clinical context, treatments, or patient-language explanation?

Ask GoDavaii AI about 1-Pyrroline-5-Carboxylate Dehydrogenase

Common questions about 1-Pyrroline-5-Carboxylate Dehydrogenase

What does 1-Pyrroline-5-Carboxylate Dehydrogenase mean in medicine?
An enzyme that catalyzes the oxidation of 1-pyrroline-5-carboxylate to L-GLUTAMATE in the presence of NAD. Defects in the enzyme are the cause of hyperprolinemia II. This definition is taken from the National Library of Medicine's MeSH (Medical Subject Headings) 2026 release, which is the standard vocabulary used to index PubMed and most medical literature.
Is 1-Pyrroline-5-Carboxylate Dehydrogenase known by any other names?
Yes. 1-Pyrroline-5-Carboxylate Dehydrogenase is also referred to as 1 Pyrroline 5 Carboxylate Dehydrogenase, Dehydrogenase, 1-Pyrroline-5-Carboxylate, GGS Dehydrogenase, Dehydrogenase, GGS in different clinical, research and patient-facing contexts. The MeSH descriptor groups all of these synonyms under a single canonical concept so research and records stay consistent.
Where does 1-Pyrroline-5-Carboxylate Dehydrogenase sit in the medical classification?
1-Pyrroline-5-Carboxylate Dehydrogenase falls under the broader medical category "Chemicals and Drugs" in the MeSH hierarchy (tree numbers: D08.811.682.662.693). Browsing the related concepts on this page takes you to neighbouring topics in the same branch of medicine.
Where can I get a plain-language explanation of 1-Pyrroline-5-Carboxylate Dehydrogenase?
For a plain-language explanation of 1-Pyrroline-5-Carboxylate Dehydrogenase - including symptoms, treatments and what it means for an Indian patient - ask GoDavaii's Health AI. It works in 22+ Indian languages, is free and needs no signup. Tap "Ask GoDavaii AI about 1-Pyrroline-5-Carboxylate Dehydrogenase" above.

Source: NIH MeSH 2026 (D050842) — National Library of Medicine, public domain. View official MeSH record ↗