Doxepin and Trazodone: High risk — avoid combining interaction. Avoid combining these medicines. Doxepin has documented drug-drug interactions in its FDA label. MAO inhibitors: Doxepin tablets should not be administered in patients on MAOIs within the past two weeks. Cimetidine: Increases exposure t

Drug InteractionHigh Risk — AvoidAI-VerifiedCategory · general

Can I take Doxepin with Trazodone?

Doxepin and Trazodone should not be combined without explicit medical guidance. Doxepin has documented drug-drug interactions in its FDA label. MAO inhibitors: Doxepin tablets should not be administered in patients on MAOIs within the past two weeks. Cimetidine: Increases exposure to doxepin. Alcohol: Sedative effects may be increased with doxepin. ( 7.3 , 5.

DoxepinMEDICINE ATrazodoneMEDICINE B
Avoid combining
Do not combine

Quick verdict

No — avoid combining Doxepin with Trazodone.

Doxepin and Trazodone should not be combined without explicit medical guidance. Doxepin has documented drug-drug interactions in its FDA label. MAO inhibitors: Doxepin tablets should not be administered in patients on MAOIs within the past two weeks. Cimetidine: Increases exposure to doxepin. Alcohol: Sedative effects may be increased with doxepin. ( 7.3 , 5.

How They Interact

The science in one sentence

Doxepin has documented drug-drug interactions in its FDA label. MAO inhibitors: Doxepin tablets should not be administered in patients on MAOIs within the past two weeks. Cimetidine: Increases exposure to doxepin. Alcohol: Sedative effects may be increased with doxepin. ( 7.3 , 5.

Why this matters

Doxepin has documented drug-drug interactions in its FDA label. MAO inhibitors: Doxepin tablets should not be administered in patients on MAOIs within the past two weeks. Cimetidine: Increases exposure to doxepin. Alcohol: Sedative effects may be increased with doxepin. ( 7.3 , 5.

Why to Avoid

Simple rules that protect you

  • Always tell your doctor/pharmacist about ALL medicines you take — prescriptions, OTC, supplements, and herbal products.
  • Keep a current medicine list with doses and timings — photo on your phone is enough.
  • Read medicine labels for timing (with food / empty stomach) before combining.
  • Do NOT combine Doxepin with Trazodone without explicit doctor approval.
  • Use GoDavaii AI to double-check before adding any new medicine, supplement, or desi ilaaj.

If you've already taken both medicines and feel unwell (unusual bleeding, severe stomach pain, confusion, breathing issues), get medical help now.

Emergency · 112
AI-Verified · Cross-checked against 40,000+ interaction database

Not medical advice

Individual responses vary based on dose, timing, health conditions, and other medicines. Always consult your doctor or pharmacist before combining medicines. For emergencies, call 112.

Frequently Asked Questions

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