High Risk Avoid combining

Can I Take Methotrexate and NSAIDs (for psoriasis) Together? — Safety Guide

Methotrexate and NSAIDs (for psoriasis) should be avoided together. NSAIDs reduce Methotrexate excretion. Toxicity risk.

Medically Reviewed by GoDavaii Health Team|Updated April 2026

Quick Answer

Methotrexate and NSAIDs (for psoriasis) should be avoided together. NSAIDs reduce Methotrexate excretion. Toxicity risk.

How They Interact

NSAIDs reduce Methotrexate excretion. Toxicity risk.

Safety Guidelines

Use Paracetamol. Short NSAID courses only with monitoring.

Important Medical Disclaimer: This drug interaction information is for educational purposes only. Always consult your doctor or pharmacist before combining medicines. Individual responses may vary based on health conditions, dosage, and other factors. GoDavaii's AI assistant can provide additional guidance in 16 Indian languages.

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