Chlorothiazide - Warnings and Precautions
The following warnings and precautions are taken directly from the US FDA-approved drug label for Chlorothiazide. This is the same information dispensing pharmacists read.
WARNINGS Intravenous use in infants and children has been limited and is not generally recommended.
Use with caution in severe renal disease.
In patients with renal disease, thiazides may precipitate azotemia.
Cumulative effects of the drug may develop in patients with impaired renal function.
Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.
Thiazides may add to or potentiate the action of other antihypertensive drugs.
Sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma.
The possibility of exacerbation or activation of systemic lupus erythematosus has been reported.
Lithium generally should not be given with diuretics (see PRECAUTIONS, Drug Interactions ).
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